Diabetes Can Be Treated Successfully Using Innovative Stem Cell Therapy

Diabetes Can Be Treated Successfully Using Innovative Stem Cell Therapy

Diabetes is not a devastating disease, If you take care of yourself following your doctor's orders, diabetes won't be a life-threatening condition. In many cases, we downplayed or simply ignored the disease's severity. When caught early, diseases can be controlled. Nature is sending us signs about every disease, but we keep missing them. We only make a big deal out of anything when it's extremely severe and going to take a long time to fix.

Diabetes, According to the World Health Organisation, 442 million persons around the world have diabetes. By 2030, this figure is predicted to rise to an estimated 520 million, a rise of 17%. Avoiding hypo- and hyperglycemia necessitates daily blood glucose monitoring and insulin injections for all Type 1 patients and the most severe instances of Type 2. Complications from diabetes include blindness, heart disease, stroke, renal failure, and even amputations of the lower extremities.

Understand Hypoglycemia, Hyperglycemia, and Child type 1 diabetes  

Hypoglycemia

Hypoglycemia occurs when blood sugar goes too low to power the body. You may feel:

Unsteady, nervous, Wet, cold, or clammy Impatient, cranky Confused, Dizzy, lightheaded, Hunger, Sleep, Weak, Lips, tongue, or cheeks tingle or numb

You may notice:

Fast heartbeat, Pale skin, Vision blurred, Headache, Nighttime sobbing or nightmares, Poor coordination, Seizures 

Hyperglycemia

Many of the aforementioned diabetes symptoms are caused by hyperglycemia or high blood sugar:

Thirsty, blurry vision,  Lots of peeing, More hunger, Foot numbness, Fatigue, Urine sugar, Weight loss, Skin and vaginal infections, Sores and cuts take longer to heal

Over 180 mg/dl blood glucose, Diabetic Coma

HHNS

The hyperosmolar hyperglycemic nonketotic syndrome is its formal name. Though more common in type 2, this dangerous consequence can cause diabetic coma and death in either type of diabetes. When blood sugar is too high and dehydrated, it happens. Symptoms include: - Blood sugar > 600 mg/dl. Parched mouth, extreme thirst, warm, dry skin without sweat, Fever exceeding 101 F, Infusion or sleepiness, Vision loss, hallucinations. Body weakness on one side

Child type 1 diabetes symptoms

• Constant thirst, increased urination, Fatigue, Vision changes, Fruity breath.
• Extreme hunger, weight loss, odd behavior
• Watch for lethargy, heavy breathing, and nausea and vomiting in your youngster. 

A "honeymoon" period,

Type 1 patients may have a "honeymoon" period, a temporary remission while the pancreas secretes insulin. Insulin users frequently experience the honeymoon phase. A week or a year might be a honeymoon. However, no symptoms do not mean diabetes is gone. Untreated, the pancreas will stop producing insulin, causing symptoms to recur.

The Type of Diabetes May Be Different

To establish the type of diabetes, see an endocrinologist if you or someone you know has type 2 diabetes and is not responding to standard therapy. Antibody and C-peptide testing are usually needed. Pancreatic insulin production releases C-peptide into the body. The pancreas produces about the same insulin and C-peptide. A blood or urine C-peptide test measures its quantity. Insulin production releases C-peptide. The test can indicate diabetes type and treatment efficacy. It can detect pancreatic cancer, renal failure, Cushing syndrome, and Addison disease.

Stem cell therapy

Vertex Type 1 Stem Cell Therapy Approved for Clinical Trials by FDA 

Briskin, Andrew

1. The FDA approved Vertex's type 1 diabetes stem cell treatment for US clinical studies. In the first half of 2023, the therapy will begin clinical trials to replace damaged insulin-producing cells in type 1 diabetes without immunosuppressive medicines.
2. The past year has seen promising advances in stem cell therapy for type 1 diabetes, despite the many obstacles.
3. For type 1 diabetes, Vertex is testing its stem cell therapy, VX-880, to replace damaged insulin-producing beta cells with healthy ones. 
4. Stem cells have not yet matured into your body's various cell kinds. Vertex can manufacture an almost endless supply of insulin-producing beta cells for type 1 diabetes in a lab with the appropriate "biological instructions." 
5. First-time VX-880 recipients boosted time in range to over 99% and glucose levels to virtually those of a non-diabetic person, according to June 2022 data. The subject needed long-term immunosuppressive medicines to prevent his immune system from attacking the new beta cells, which was a difficulty.
6. Vertex is exploring another new medication, VX-264, that puts beta cells in an enclosed device to shield them from the immune system while letting nutrients reach them. This strategy is encapsulation. 
7. Vertex can commence encapsulated stem cell treatment (VX-264) clinical trials after FDA approval on March 9. Vertex will begin clinical trials for encapsulated insulin-producing stem cells in the first half of 2023. The medicine was already cleared for clinical trials in Canada, where an early trial is underway.
8. VX-264 employs stem cell-derived beta cells like VX-880. In September 2019, Vertex bought Semma Therapeutics, a privately held biotechnology company pioneering the use of stem cell-derived human islets as a potentially curative treatment for type 1 diabetes,) which had been developing a channel array device for years.
9. Vertex has shown that protected cells can restore insulin production in T1D patients, so encapsulating the cells in a specially designed device may make the therapy safer and more convenient for type 1 patients and eliminate the need for long-term immunosuppressive medication.
10. "Research advances can only make an impact if they reach clinical trials and T1D patients can participate," stated Felicia Pagliuca, Vertex's Disease Area Executive, Type 1 Diabetes.  This is the first clinical trial of device-encapsulated stem cell-derived islets. We will continue to develop novel T1D medicines.

Using radiation

Diabetes Care 2030: 5 Trends that could change management

This article by Alcimed discusses five developments that could change diabetics' lifestyles by 2030.

1. Non-invasive glucose monitoring using radiation

Infrared, Raman, thermal, photoacoustic, and millimeter waves can monitor blood glucose content remotely, punctually, or constantly, without stinging.

The earlobe-mounted GlucoTrack device is one example. GlucoWise, a thumb-index finger patch, K'Watch, a connected watch, and SugarBeat, an arm patch, are under development.

The majority of diabetics are non-insulin-dependent, hence the argument over whether these devices should be used continues. Continuous glucose monitoring for these patients could be adopted and reimbursed by healthcare systems if its clinical benefits are shown.

2. Smart insulin that detects high blood glucose
Smart insulin stays in circulation for a long period yet activates when glucose levels rise. This approach would eliminate blood glucose monitoring, simplifying diabetics' lives.
There are two options: developing a glucose-reactive insulin molecule or encapsulating insulin in a glucose-reactive substance. The following firms are involved. Thermalin Diabetes, Glycostasis, Ziylo, Sensulin, and Zenomics are involved in this field, as is the JDRF.

3. Insulin resistance treatment bioartificial pancreas

Another potential lead would give the pancreas insulin-producing cells. Stem cells mature human cells, and pig beta cells (insulin-producing pancreatic cells) have shown promise. An encapsulation system protects these cells from the immune system while releasing insulin and oxygen. Viacyte, a leading company in this field, is testing a new treatment in Phase I.

4. Type 1 diabetes immunotherapy vaccination

Immunotherapy may prevent Type 1 diabetes by delaying pancreatic cell self-destruction, like with other autoimmune disorders. All patients with a hereditary susceptibility to the condition may benefit from this therapy.

Massachusetts General Hospital is developing a tuberculosis vaccine, Provention Bio is developing a monoclonal antibody, and Imcyse is modifying synthetic peptides. Clinical trials are increasing, benefiting future diabetics.

5. The gut microbiome fights type 2 diabetes.

Finally, some recent studies demonstrate a definite link between gut microbiota and Type 2 diabetes: the lack of an unknown combination of bacteria would greatly contribute to obesity and Type 2 diabetes.

This research could lead to fecal microbiota transplants from healthy donors to diabetics. This therapy would significantly reduce weight and improve blood sugar management.

The Netherlands' University of Amsterdam, France's ICAN, Sweden's University of Gothenburg, and the US's University of Washington are among the many universities and research institutes working in this media-covered field.

The authors desired to share their treatment.

Conclusion.

While prospects are high, totally non-invasive technologies and curative diabetes therapies are still far off. As create more creative treatments, will have to address the rising prevalence of diabetes, healthcare system expenditures, and geographical discrepancies in care.