Type 1 Diabetes Cured Using Stem Cell Transplant.
Overview
For a long time, everyone in the cosmos believed that Type 1 diabetes has no treatment. This is now in the past, and there has been a breakthrough in the hope of curing Type 1 diabetes. The Chinese medical community and scientific community used stem cell transplantation to find a treatment. Patients with type 1 diabetes who have exhausted all other treatment options will find this a godsend. The story is worth discussing.
Claims Chinese Scientists Can Cure Type 1 Diabetes Through Stem Cell Transplant, Doing Away With Insulin
Reprogrammed stem cells
A story, of a woman with type-1 diabetes was reportedly cured by Chinese doctors who used a minimally invasive transplant of her reprogrammed stem cells. This procedure completely removed the need for insulin shots.
According to Chinese scientists, stem cell transplants were all it took to cure a 25-year-old woman of her chronic diabetes. Shanghai-based Chinese news outlet The Paper reports, which was cited by news agency PTI, that the Tianjin woman had chronic type-1 diabetes. After the procedure, which took just 30 minutes to complete, the woman was able to naturally control her blood sugar levels about 2.5 months later with few incisions.
The groundbreaking team's results were published in last week's issue of the peer-reviewed journal Cell.
The study included academics from Tianjin First Central Hospital and Peking University, according to the newspaper.
Who took care of her?
Last June, the Chinese research team successfully transplanted their first patient after receiving formal approval for a clinical study.
Islets generated from "chemically induced pluripotent stem cells," or CiPSCs, were allegedly used in the treatment, according to a paper in the Cell.
Researchers accomplished this by first obtaining cells from the patient's adipose tissue and then reprogramming them into pluripotent stem cells using small-molecule compounds. Reintroduced to the patient's body, these cells underwent a process of differentiation into islet cells. There was no immunological rejection because these pancreatic cells were patient-derived.
Eleven years ago, the woman received a diagnosis of type 1 diabetes; she has since survived two liver transplants and a failed pancreatic islet cell transplant. She had a history of severe hypoglycemic episodes and large fluctuations in blood sugar levels.
Following the CiPSC islet transplant, her fasting blood glucose levels returned to normal, and she began to rely less and less on exogenous insulin.
75 days after the transplant, it was reported that she was no longer in need of insulin shots, and five months after the transplant, her blood sugar levels remained stable within the target range more than 98% of the time.
What was the location of the cell transplant?
To circumvent the potential for inflammation that is associated with conventional islet transplants, the researchers opted to transplant the cells into the abdominal muscles rather than the liver, thus streamlining the surgical process, according to the report.
Because of the shallow injection site, image monitoring was possible, and the cells could be removed whenever necessary, the procedure was quite painless.
Video is more information.
"The clinical data met all study endpoints with no indication of transplant-related abnormalities," the procedure's backers wrote in a report written a year after the operation.
The researchers concluded that additional clinical trials using CiPSC islet transplants in type 1 diabetes are necessary because of the patient's encouraging outcomes.
What is the standard procedure While doing a TRANSPLANT,?
Harvesting islet cells from a donor's pancreas and transplanting them into a patient with type 1 diabetes's liver is the standard procedure for an islet transplant.
The lack of available donors is preventing this approach from being fully realized as a promising treatment.
Hormones such as insulin and glucagon are manufactured by pancreatic islet cells and secreted into the bloodstream to regulate glucose levels.
According to the paper, stem cell therapy has now created new opportunities for the treatment of diabetes.
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